TimTec NPL (Natural Product Library) is a library of 720 natural compounds composed of pure natural products as lead identifying materials. Compounds are primarily sourced from plants with the remaining samples from bacteria, fungus, and animal sources.
Diversity by nature Purity by science Value by design
NPL is sold as a complete collection or by plate or by individual compounds; available in solid form or in DMSO solution at pre-plated or at custom concentration.
Rediscovering Natural products Article: Interest in natural compounds is on the rise.
TimTec NPL Featured Screening Results
TimTec Natural Product Library was screened to identify compounds that significantly reduce infectivity without cytotoxicity. NPL collection featured 280 compounds at the time of the moderate-throughput screening. MTS assay is adaptable to different virus systems.
Out of 280 compounds, 15 molecules showed antiviral activity and were identified as promising models for immunomodulatory agents. Download available compounds that reduce rotavirus infectivity without cytotoxicity.
Shaneyfelt, M. E., et al. Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay. Virology Journal, 2006, 3:68doi:10.1186/1743-422X-3-68
"We recently published our paper on the AhR and utilized your NPL library as part of a physical and virtual screen.Thanks for all your help, and if any of your scientists need any help understanding what we did, feel free to contact me again." - Dan Koch
Bisson H., et.al. Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and Its Utility in Virtual Ligand Screening to Predict New AhR Ligands. J.Med. Chem. 2009 Sept, 52 (18), 5635-5641
View available from stock activators of AhR transcription based on initial in silico screening
Jadhav A., et al. Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010Jan 14;53(1):37-51
Nielsen AL, Kristensen LH, et. al. Identification of catechols as histone-lysine demethylase inhibitors. FEBS Lett. 2012 Apr 24;586(8):1190-4. Epub 2012 Mar 15. doi:10.1016/j.febslet.2012.03.001
NPL is one of TimTec nature-inspired collections. Natural Derivatives Library (NDL-3000) elaborates on structural diversity of pure natural molecules and includes natural derivatives, analogs, semi-natural compounds, and mimics. There is no overlap between NPL and NDL compounds. Learn more about the Natural Derivatives Library design approach.
Flavonoid derivatives collection, FL-500
Plant Extracts, crude mixtures of compounds
Chem-TCM Database of molecular records, constituents of plants used in traditional Chinese medicine
TimTec Pure Natural Products Library Purchasing Terms
TimTec Pure Natural Products Library (NPL) includes primarily known natural compounds that are also available through a number of domestic and international commercial sources. The value of the library design is in the broad diversity of selected natural material available in screen-ready format. TimTec does not hold any intellectual property (IP) rights for compounds in our collections nor is responsible for any damages that may result from TimTec products use. TimTec products are for R&D use only and should be handled by trained personnel.