Flavonoids make one of the most preferred groups of natural chemotypes tested for various biological activities. Flavonoids have low toxicity and are widely available in plants.
This group of compounds provides a good example of “natural fit” holding leading performance in anti-inflammatory, anticancer, anti-oxidant activities.
9 core Flavonoid structures are used to assemble TimTec small collection of 500 Flavonoids Derivatives.
| Chalcone | Flavanone | Flavone |
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| Anthocyanin | Isoflavonoid | Neoflavonoid |
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Download TimTec small collection of 500 Flavonoids Derivatives
Selected Reference:Watternberg, L. W., et al. Inhibition of carcinogen-induced pulmonary and mammary carcinogenesis by chalcone administered subsequent to carcinogen exposure. Cancer Lett. 1994, 83, 165-169
Lo Piparo E., et al. Flavonoids for Controlling Starch Digestion: Structural Requirements for Inhibiting Human alpha-Amylase. J. Med. Chem., 2008, 51 (12), pp 3555–3561
Daskiewicz J-B., et al. Effects of Flavonoids on Cell Proliferation and Caspase Activation in a Human Colonic Cell Line HT29: An SAR Study. J. Med. Chem., 2005, 48 (8), pp 2790–2804
Following the screens of TimTec compounds and compound collections involving flavonoids:Holder S., et al., Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther. Jan. 2007, 6(1), 163-172
Bullock A.N., et al. Structural Basis of Inhibitor Specificity of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM-1) Kinase. J. Med. Chem., 2005, 48 (24), pp 7604–7614
Auld, D. S., Characterization of Chemical Libraries for Luciferase Inhibitory Activity. J. Med. Chem., 2008, 51 (8), pp 2372–2386
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